Brand name: Zoloft

Available as 25 mg, 50 mg, 100 mg. film-coated tablets, or 20 mg/mL oral solution.

150 mg and 200 mg are available in capsules.

Sertraline hydrochloride is a medication prescribed for dogs and cats whose fear and anxiety cause behavioral issues. This medication is used widely in humans for the treatment of some common conditions, like depression, anxiety, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

In pets, this medication is used to reduce compulsive and stereotypical behaviors. Compulsive behaviors are normal behaviors done in an abnormal way (too much, too often), like excessive chewing, barking, eating or drinking. Stereotypical behaviors are similar, but they don’t seem to have an obvious purpose and are thought to be soothing to the pet. Examples of these behaviors in pets could be licking, sucking, pacing or circling. While behaviors like these may seem harmless, it could be your pet’s way of communicating their feelings.

How this Medication is Used

Sertraline hydrochloride is a selective serotonin-reuptake inhibitor (SSRI). Serotonin is a hormone that carries messages between a pet’s brain and body, helping to make them feel happy and calm. These medications keep serotonin in the brain longer, which can help with behavioral issues that are caused by fear and anxiety. 

There is no form of sertraline available on the market for pets, so your veterinarian is permitted to prescribe your pet the human form of this medication. When prescribing this medication, your veterinarian will give you a set of specific dosing instructions. It is important to give this medication to your pet exactly as instructed so that it can properly help your pet.

Side Effects

Sertraline is known to cause diarrhea, vomiting, and poor appetite in some pets. Some added risks of bleeding can be seen in some pets, such as nose bleeds and bruising.

Suddenly stopping treatment with an SSRI can lead to agitation, irritability, anxiety, confusion, and lethargy

Interactions with Other Drugs

Use of another medication that leads to the production or accumulation of serotonin can cause severe side effects and may lead to toxicity. Your veterinarian should be made aware of any medications or supplements your pet is currently taking before prescribing an SSRI.

Concerns and Cautions

Sertraline is mainly removed from the body by the liver in bile, so normal liver function is needed to eliminate the drug from the body. If liver function is decreased, dose adjustments may be required.

The tablets and oral suspension must both be stored at room temperature (approximately 25°C/77°F).