Powered by Google

Sorry, something went wrong and the translator is not available.

Sorry, something went wrong with the translation request.

loading Translating

Dexmedetomidine (Sileo, Dexdomitor)
Revised: June 08, 2024
Published: June 13, 2016

(For veterinary information only)

The size of the tablet/medication is NOT an indication of a proper dose. Never administer any drug without your veterinarian's input. Serious side effects or death can occur if you use drugs on your pet without your veterinarian's advice. 

It is our policy not to give dosing information over the internet.

Brand Name: Sileo, Dexdomitor

Available as oral gel, injectable                  


Noise aversion can be a serious problem for a pet dog. Not only is the associated panic unpleasant but the frightened animal can become destructive or even dangerous. It is not unusual for a terrified dog to break down doors or even windows in an escape attempt. The dog may bite or potentially escape from a yard or pen and become lost. The dog is experiencing a panic disorder and likely could do with pharmacological assistance in times when loud noises are expected.

Past remedies have involved acepromazine, which induces drowsiness and impairs mobility without a lot of anxiety reduction. Benzodiazepine tranquilizers, such as alprazolam, have been felt to be superior for relief of panic. In 2016, an oral form of dexmedetomidine became available for use in dogs with noise aversion.

Dexdomitor has been widely used in veterinary anesthesia for decades because it is effective, reversible, and provides good analgesia. The oral gel released for noise phobia uses a low dose of this medication so as to relieve anxiety without inducing sedation. It has applications for other types of anxiety or fear beyond noise phobia and could be used for anxiety associated with travel, visits to the vet, large numbers of visiting guests, or other similar stressful events.

How this Medication is Used

Dexmedetomidine oral gel is administered in the dog's cheek pouch rather than the mouth. The person administering the medication should wear gloves when handling the syringe and medication is ideally given 30-60 minutes before the noise or stressful event is expected. Medication is ideally given 30 to 60 minutes before the noise is expected. Additional doses may be given if necessary but it is important to wait at least two hours between doses. Up to five doses can be given per noise event.

The syringe applicator comes with a dial-up dosing handle. It is important to know where to dial your pet's dose is on the handle. It is equally important to be sure the syringe dial is locked so that when you put the syringe in your dog's mouth and push the plunger, only the correct amount is delivered. If the dial is not locked, your dog can be overdosed, so be sure you understand how the syringe correctly. See a how-to video.

If your dog's dose is six dots or more, it is best to split the dose so that half is given in the right cheek pouch and half is given in the left.

If you miss a dose, wait two hours before giving another dose. This medication can be given up to five times per day as long as at least two hours pass between doses.

If dexmedetomidine is delivered in the mouth and not the cheek pouch, it will not absorb properly and will not be effective. If this happens, wait two hours before re-dosing.

Store the syringe inside the box as the product is light-sensitive.

Do not feed your dog for 15 minutes after giving it.

This product can be used up to five times in a 24-hour period as long as at least two hours pass between doses.

Interactions with Other Drugs

Use of this product with other tranquilizers or anti-anxiety medications can increase the potential for side effects. Be sure your veterinarian is aware of all other medications your dog uses. 

Side Effects

The dog's gums may appear pale shortly after administration of dexmedetomidine gel. This is insignificant and can be considered a normal reaction if it occurs.

Dexmedetomidine has the potential to lower blood pressure and heart rate. However, neither of these effects should be significant in normal patients.

Dexmedetomidine is an anesthetic drug but should not cause sedation at these doses. That said, sedation might be seen in a sensitive animal.

Concerns and Cautions

Dexmedetomidine gel is for healthy dogs. It should not be used in dogs with heart disease, kidney disease, respiratory compromise, exhaustion, or heat stress.

The dosing syringe is good for four weeks after being opened and may be used again within that time frame.

Dogs with more deep-seated or long-term anxiety (rather than just fear of loud noises that occur only periodically) will need a different treatment plan. Dexmedetomidine is for dogs who suffer from noise aversion but not from general anxiety.

The safety of this product has not been evaluated in puppies under 16 weeks of age or in pregnant or nursing female dogs.

The manufacturer recommends that pregnant women not handle this product.

The content of this site is owned by Veterinary Information Network (VIN®), and its reproduction and distribution may only be done with VIN®'s express permission.

The information contained here is for general purposes only and is not a substitute for advice from your veterinarian. Any reliance you place on such information is strictly at your own risk.

Links to non-VIN websites do not imply a recommendation or endorsement by VIN® of the views or content contained within those sites.