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Diphenhydramine (Benadryl, Vetadryl, Banophen, Diphenhist)
Revised: October 28, 2023
Published: January 01, 2001

(For veterinary information only)

The size of the tablet/medication is NOT an indication of a proper dose. Never administer any drug without your veterinarian's input. Serious side effects or death can occur if you use drugs on your pet without your veterinarian's advice. 

It is our policy not to give dosing information over the internet.

Brand Name: Benadryl, Vetadryl, Banophen, Diphenhist

Available in 25 mg & 50 mg capsules; 10 mg, 12.5 mg, and 30 mg chewable tablets; 50 mg tablets, oral elixir, and syrup


Histamine is an inflammatory biochemical that causes skin redness, swelling, pain, increased heart rate, and blood pressure drop when enough of it binds to enough of the many H1 receptors throughout the body. Histamine is an important mediator of allergy in humans, hence a spectacular array of different antihistamines has proliferated. Histamine, perhaps unfortunately, is not as important a mediator of inflammation in pets, which means results of antihistamine therapy are not as reliable in pets.

How this Medication is Used

Diphenhydramine has several important effects and, thus, several uses. Most obviously, diphenhydramine is an antihistamine, and it is used for acute inflammatory and allergic conditions such as:

• Bee stings and insect bites
Vaccination reactions
Snake bites

Diphenhydramine is frequently prescribed to treat itchy skin, though recent evidence-based guidelines for allergic skin disease have not found it to be particularly helpful except possibly in acute reactions involving hives. It may create enough drowsiness to reduce scratching but does not seem very supportive in actually reducing itch. See more information on managing itchy skin.

Diphenhydramine can be given with or without food.

Diphenhydramine should be stored at room temperature, away from light.

Mast cell tumors are tumors involving cells that contain granules of histamine. Patients with mast cell tumors experience chronic inflammatory symptoms due to circulating histamine. Antihistamines such as diphenhydramine may be helpful given long term.

Diphenhydramine has a strong anti-nausea side effect that makes it helpful in treating motion sickness. This affects dogs but does not apply to cats.

Diphenhydramine causes drowsiness in animals just as it does in people and can be used as a mild tranquilizer. Given that there is an anti-nausea effect in dogs as well as a tranquilizing side effect, it can be used for traveling situations where very light effects are needed. There are stronger anti-nauseals (such as maropitant) and stronger tranquilizers (such as acepromazine).

Side Effects

With so many possible uses of this medication, it is difficult to separate out a side effect from a primary effect. Drowsiness is generally regarded as an undesirable side effect, but in certain circumstances, as mentioned, it might be the primary desired effect.

At doses higher than recommended, people complain of dry mouth, constipation, and difficulty with urination.

Diphenhydramine can interfere with intradermal skin testing for allergy. Ask your veterinary dermatologist for instructions on withdrawal of this medication before testing.

Occasionally a cat will experience excessive excitement on diphenhydramine, necessitating confinement for everyone's safety. This side effect is rare.

Interactions with other Medications

In the treatment of allergic skin disease, antihistamines are felt to synergize with omega 3 fatty acid supplements, and, as a general rule for this condition, it is best to use these medications together.

Diphenhydramine should not be used with additional tranquilizing medications as the tranquilization effect can be inappropriately enhanced. In animals that experience a hyperactivity reaction while taking metoclopramide (Reglan), this effect can be reversed with a dose of diphenhydramine.

The side effects of dry mouth, increased heart rate, and difficulty urinating are more likely when diphenhydramine is used in conjunction with a tricyclic antidepressant (such as clomipramine) or with an MAO inhibitor such as selegiline.

Concerns and Cautions

Image of Benadryl Allergy /Sinus tabs
This product contains a combination of medications with substantial potential for harm if given to a pet. Images Courtesy Dr. Wendy Brooks

If a dose is accidentally skipped, do not double up on the next dose. Store at room termperature.

Be careful of oral liquids containing alcohol. These formulations should not be used in pets.

It is important to realize that the word Benadryl is a brand name and there are many different products sold under this name. Likewise, there are generics that include diphenhydramine that also include inappropriate ingredients. To emphasize this point, we show such a product below. It seems like it would contain diphenhydramine; however, it contains a combination of diphenhydramine and other medications, including a dose of acetaminophen that could be lethal to a pet.  Recently a veterinary product has become available. This is a scored chewable tablet that facilitates administration and proper dosing to pets and circumvents the potential for toxic additives.

Image of Benadryl Alllergy only tabs
This product contains only diphenhydramine, with no additional medications added. Image Courtesy Dr. Wendy Brooks

Never buy over-the-counter medication for your pet without knowing exactly what you are supposed to get and never medicate your pet without your vet’s guidance.

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