Brand Names: Ivomec, Heartgard & Heartgard Plus, Iverhart Plus & Iverhart Max, Pet Trust, Tri-Heart Plus

Available in tablets and chewables for heartworm prevention, or as an oral or injectable solution for other parasite problems      

How this Medication is Used

In the mid-1980s, ivermectin was introduced as probably the most broad-spectrum anti-parasite medication ever. It was an absolute revolution in parasite control for livestock and horses, and for dogs, it forever changed heartworm prevention from a daily pill to a monthly one.

Ivermectin is effective against roundworms, hookworms, most mites, and some lice. It is not effective against fleas, ticks, flies, or flukes. It is effective in killing larval heartworms (the microfilariae that circulate in the blood) but does not kill adult heartworms that live in the heart and pulmonary arteries, though technically, it can shorten their lifespan.

The most common uses in small animal practice for ivermectin include:

• Monthly prevention of heartworm infection
• Treatment of ear mite situations
• Clearing heartworm larvae in active heartworm infection
• Treatment of sarcoptic, notoedric, or demodectic mange.

There are two dosing schedules: "label" use which refers to commercial heartworm products and "off label" use for other parasites such as mange mites. It should be noted that doses of ivermectin used for prevention and treatment of heartworm disease are approximately 50 times lower than doses used for other parasites, a fact that has allowed for FDA approval of ivermectin products for the prevention of heartworm but not for external parasite protection.

Label Doses

Ivermectin is used monthly for the prevention of heartworm infection.

If a dose is accidentally skipped, do not double up on the next dose. Simply give the medication when it is remembered or pick up with the next dose, allowing at least the proper interval between doses according to the label instructions. If the dose skipped was a heartworm preventive, there is an approximately 2 week "grace period" but if more than 2 weeks have past since the dose was due, your pet is vulnerable to heartworm infection until the dose is given again.

The same label dosed products can be used to kill heartworm larvae in an active infection. Special doses are not needed for this situation.

Off Label Doses 

Ivemectin can be used against mange mites, ear mites and some lice. The doses needed against these parasites are substantially higher than those needed for heartworm prevention. Doses are high enough to cause toxicity in certain indviduals, particularly those (usually collie type breeds) with the MDR-1 mutation (see below).  That said, the advent of the isoxazoline class of parasite drugs (Credelio®, Bravecto®, Nexgard® and Simparica ®) have largely made the use of ivermectin for externa parasites obsolete. 

Side Effects

Side effects are not a concern with the extremely low doses used in commercially marketed heartworm preventives. When off-label doses, as in mange or mite treatment, problems can arise if the patient has an undiagnosed P-glycoprotein gene mutation.

In normal patients, the P-glycoprotein is involved in keeping drugs out of certain tissues and is important in keeping ivermectin out of the patient's nervous system. A healthy P-glycoprotein system allows ivermectin to be safe for mammals, even in very high doses. Unfortunately, collie-related breeds (and some other breeds) commonly have a mutation in the genes that make P-glycoprotein. (This has been called the MDR1- mutation but has recently been renamed the "ABCB1-1" mutation.) This mutation can create dangerous ivermectin sensitivity. Normal commercial heartworm preventives do not use high enough doses for this issue to come into play; it is usually during treatment of demodectic or sarcoptic mange when the issue comes up.

• Side effects of concern with higher doses include dilated pupils and drunken gait that can progress to respiratory paralysis and death if medication is not withdrawn and supportive care is not initiated.

Without a DNA test, a low-dose test protocol can be used. In this protocol, a low dose is started, and the patient is observed for dilated pupils or drunken gait. If no problems are seen, the dose can be raised to the therapeutic dose with less concern.

Again, heartworm preventive are generally safe for dogs with MDR1 drug sensitivity when given at the low, FDA-approved doses.

Interactions with Other Drugs

Ivermectin should not be used with spinosad (Comfortis or Trifexis) as the potential for ivermectin side effects will be increased. Again, the small doses of ivermectin used in heartworm prevention are not included in this cautionary statement; this only applies to the high-dose protocols used to treat skin parasites.

Concerns and Cautions

Ivermectin use in pregnancy and lactation is not felt to be a problem.

Ivermectin has an extremely bitter taste. Some animals may object.

Again, the breeds classically considered at high risk for ivermectin toxicity are collies, Shetland sheepdogs, Australian shepherds, merle-colored Pomeranians, and Old English sheepdogs. This list is not exhaustive, and many consider any dog with white feet to be potentially affected by the MDR1 mutation. Not every individual dog from these breeds is sensitive to ivermectin. It is possible to test an individual using a low dose of ivermectin. These breeds are not at risk for trouble when using the low-dose heartworm preventive products, but only when using the off-label skin parasite protocols.

Oral or injectable ivermectin is not recommended for patients under the age of six weeks.